Research & Commercial Manufacturing

Analytical chemistry at WuXi AppTec provides analytical and separation services to support discovery and process chemistry.

Chiral Separation Services

Systematic method development approach column/mobile phase screening technology by SFC and HPLC
Preparative separations using SFC and HPLC platforms
AD, OD, AS, OJ, IC columns up to 5 cm diameter
Rapid turn-around time - able to deliver separated isomer within 5 working days

Large Scale Chromatography Separation Services

Both chiral and achiral
SFC, HPLC, MPLC platform with columns up to 11 cm diameter
Capability to separate kilograms per day

High-throughput Purification Services

MS and UV triggered Prep HPLC fraction collection
Standard LC-UV-ELSD-MS platform for QC of isolated compound
Capability to purify and characterize 1,000,000 compounds annually

Natural Product Purification

Method development and validation
GLP compliance
Gram-to-kilogram natural product purification capability

High-throughput Physical Property Determination

Thermodynamic and kinetic solubility
Log P/log D determination utilizing shake-flask or chromatography method
Pka determination

Isolation and Structure Elucidation for Impurities

Isolate impurity by various methods including HPLC, SPE, LLE, etc.
Elucidate structure by the combination of various analytical techniques, including NMR, LC-TOF MS, EA, IR, etc.