Synthetic & Medicinal Chemistry
With full synthetic and medicinal chemistry capabilities, WuXi AppTec’s strong and experienced scientific leadership team and over 1,600 chemists are dedicated to creating molecules per our clients’ needs.
Synthetic Chemistry
- Custom Synthesis of Intermediates and Benchmark Compounds
Completed syntheses of kazusamycin A, Eudistomin analogs, BILN-2061, Aliskiren, etc., each of which was synthesized via >30 synthetic steps.
Synthesized over 10,000 individual compounds with an average of eight synthetic steps in gram to kilogram quantities.
Success rate over 95%.
- Chemi-Informatics for library design, execution and analysis
- Reagents, enumeration, plate layout, RO5 compliance, calculated physical properties, quality control SAR analysis
- Diversity Library Design and Synthesis
Utilizing our deep understanding of medicinal chemistry and aided by our Computational Chemistry Support team, we design and synthesize drug-like templates and libraries of compounds to enhance our clients' compound collections.
Library production annual capacity is 1,000,000 compounds, with each compound >20 mg and >85% purity.
- More than 2,000 Drug-like spirocyclic, fused and rigid bridgehead heterocyclic templates now available for purchase
